Synthesis and Antimicrobial Screening of some Mannich Bases of Isatin
نویسندگان
چکیده
منابع مشابه
synthesis and characterization of some macrocyclic schiff bases
ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اولSynthesis and Screening of Some New Isatin Containing Thiazole Derivatives for Antimicrobial Activity
In the present work, a series of new N’-[{5-(4-aryl) 1,3-thiazol-2yl}carbohydrazide-methyl]- 3(4-arylimino) indol-2-one analogs (5a-g) had heen synthesized from 3-(4-arylimino)-2-oxo- 1-indole-acetylthiosemicarbazide (4a-g) in ethanol, in the presence of phenacyl bromide or substituted phenacyl bromides. The compound 5e was characterized by its elemental analysis, IR, 1 HNMR and Mass Spectrosco...
متن کاملPanda: Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases
In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The NMannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemica...
متن کاملSynthesis and Antimicrobial Activity of Some New Isatin Derivatives
Some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-H-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (VIII) have been synthesized from different isatinhydrazones (II) by condensing with 2-phenyl-5-benzylidene- 3-N (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (VII). Their chemical structures have been confirmed by IR, 1HNMR, MASS and by elemental analysis. Investigation of antimicrobial ac...
متن کاملSynthesis of some isatin Schiff bases in microwave irradiation condition
An efficient and mild methodology for rapid and efficient synthesis of isatin Schiff bases was described under microwave irradiation and solvent free condition.aromatic or heterocyclic Primary amines and isatin could be selectively reacted under microwave irradiation into the corresponding isatin Schiff bases in high yields and short reaction time.
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Research
سال: 2009
ISSN: 2454-8405,0973-7200
DOI: 10.18579/jpcrkc/2009/8/2/79772